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Piezo comes from the Greek ‘piesi’ meaning pressure. It is derived from the Greek word πιέζειν; piezein, which means to squeeze or press, and ἤλεκτρον ēlektron, which means amber, an ancient source of electric charge.

Piezoelectricity is the electric charge that accumulates in certain solid materials—such as crystals, certain ceramics, and biological matter such as bone, DNA, and various proteins—in response to applied mechanical stress. For example, with applied Terahertz waves.

PIEZO1 gene is a mechanically-activated ion channel that links mechanical forces to biological signals.

Therefore, applying Terahertz frequency waves impacts PIEZO1 via mechanical force.

Stems cells are thought to be the ‘Fountain of Youth’ and have the capability to migrate, develop and differentiate into different types of cells such as adipocytes, osteocytes or chondrocytes.

It is this unique plasticity that makes the endometrial mesenchymal stem cells (eMSCs) significant for cellular therapy and regenerative medicine.

In fact, the NANOG gene involved with stem cells was named after the Tír na nÓg; (“Land of the Young“) or Tír na hÓige (“Land of Youth”). Other Old Irish names for the Otherworld include Tír Tairngire (Land of Promise/Promised Land), Tír fo Thuinn (Land under the Wave), Mag Mell (Plain of Delight/Delightful Plain), Ildathach (Multicoloured Place), and Emain Ablach (the Isle of Apple Trees).

Sounds a lot like eternal youth and paradise!

Stem cells choose their way of development by analyzing the extracellular and intracellular signals generated by a mechanical force from the microenvironment.

Mechanosensitive channels are part of the cellular toolkit that feels the mechanical environment and can transduce mechanical stimuli to intracellular signaling pathways.

A recent study reveals that…

“Piezo1 activity triggered by the channel agonist Yoda1 elicits influx of Ca2+, a known modulator of cytoskeleton reorganization and cell motility. We found that store-operated Ca2+ entry (SOCE) formed by Ca2+-selective channel ORAI1 and Ca2+ sensors STIM1/STIM2 contributes to Piezo1-induced Ca2+ influx in eMSCs.”

In Greek mythology, the ‘Orai’are the keepers of the gates of heaven: Eunomia (order or harmony), Dike (justice) and Eirene (peace).

In simple terms what does all this mean?

The piezoelectric effect that occurs via terahertz frequency transduces an intracellular signal to stem cells (eMSCs) by way of modulating a calcium signaling gene called ORAI1, which is related to the keepers of the gates of heaven.

You can kind of think about it like this…

The Terahertz Frequency is a bit like opening up the gates of heaven here on earth and gaining access to the fountain of youth.

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